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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment selection for chronic weight loss in addition to a reduced-calorie diet and exercise. Using two separate drugs to shed weight can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err on the side of caution and let the FDA do its job and demand some research be done so that the public understands the side effects and risks of the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say everything to keep people on their medications. Researchers found that participants taking this drug for the year, dropped a few pounds within one month and have kept the load off through the entire 56 weeks with the study. Contrave can be a combination with the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which are made up of more than one active ingredient, which can make them more effective and safer. Combo-pilling will be the newest fad or also the newest into the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular could be the fact that as of right now there aren't long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug may also raise blood pressure and pulse rate, and really should not be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise hypertension and pulse rate and must stop used in patients with uncontrolled high blood pressure level, along with by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients having a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients for the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking. "There were no indications of depression or suicidal thoughts in trial participants," said Fujioka.
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